Immunoglobulin IgA – Laboratory Test Ranges | Reference

Immunoglobulin A (IgA)

Reference range

Age	Value IgA, g/L
< 2 months	0,02 – 0,5
2 – 5 months	0,04 – 0,8
5 – 9 months	0,08 – 0,8
9 – 12 months	0,15 – 0,9
12 – 24 months	0,15 – 1,1
24 months – 3 year	0,18 – 1,5
3 – 5 years	0,25 – 1,6
5 – 8 years	0,35 – 2,0
8 – 12 years	0,45 – 2,5
children > 12 years and adult	0,4 – 3,5

Increased IgA:

• Wiskott – Aldrich;
• chronic purulent infections, especially gastrointestinal
  and respiratory tract (asthma, tuberculosis);
• autoimmune diseases such as rheumatoid arthritis
  (early stage);
• multiple myeloma (IgA – type);
• cystic fibrosis;
• asymptomatic monoclonal (IgA) gammopathy;
• chronic liver disease (hepatitis, cirrhosis);
• enteropathy;
• alcoholism.

Decreased IgA:

acquired deficiency:

• lymphomas and lymphoproliferative disease;
• state after splenectomy;
• loss of protein in the entero-and nephropathy;
• immunosuppressive therapy, cytostatics;
• exposure to ionizing radiation;
• malignant anemia, hemoglobinopathies;
• atopic dermatitis.

congenital deficiency:

• agammaglobulinemia (Bruton’s disease);
• ataxia-telangiectasia (Louis-Bar syndrome).

other causes:

• long-term exposure to benzene, toluene and xylene;
• intake dextran, methylprednisolone, estrogen,
  carbamazepine, valproic acid, preparations of gold (krizanol, auranofin).